General references on magnesium
[1] Volpe SL. Magnesium in disease prevention and overall health. Adv Nutr. 2013 , 4, 378S.
[11] Nutritional references for vitamins and minerals. ANSES 2025.
Magnesium and sleep
[2] Abbasi B et al. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci. 2012, 17, 1161.
[3] Khalid S et al. Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus. Front Endocrinol, 2024, 15, 1370733.
[7] Hornyak M et al. Magnesium therapy for periodic leg movements-related insomnia and restless legs syndrome: an open pilot study. Sleep. 1998, 21, 501.
[8] Gorantla S et al. Magnesium citrate monotherapy improves restless legs syndrome symptoms and multiple suggested immobilization test scores in an open-label pilot study. J Clin Sleep Med. 2024, 20, 1357.
Magnesium, stress and mental health
[4] Botturi A et al. The Role and the Effect of Magnesium in Mental Disorders: A Systematic Review. Nutrients. 2020, 12, 1661.
[5] Pickering G et al. Magnesium Status and Stress: The Vicious Circle Concept Revisited. Nutrients. 2020, 12, 3672.
[6] Cuciureanu MD et al. Magnesium and stress. In: Vink R, Nechifor M, editors. Magnesium in the Central Nervous System [Internet]. Adelaide (AU): University of Adelaide Press; 2011.
Magnesium, inflammation and muscles
[9] Veronese N et al. Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials. Nutrients. 2022, 14, 679.
[13] Sankova MV et al. Magnesium deficiency and its interaction with the musculoskeletal system, exercise, and connective tissue: an evidence synthesis. Sport Sci Health 2024, 20, 715.
Magnesium bioavailability
[10] Schuette SA et al. Bioavailability of magnesium diglycinate vs magnesium oxide in patients with ileal resection. J Parenter Enteral Nutr. 1994, 18, 430.
[15] Schuchardt JP et al. Intestinal Absorption and Factors Influencing Bioavailability of Magnesium-An Update. Curr Nutr Food Sci. 2017, 13, 260.
Glycine and sleep
[11] Inagawa, K et al. Glycine ingestion improves subjective sleep quality in human volunteers, correlating with polysomnographic changes. Sleep Biol Rhythms, 2007, 5, 126.
[12] Kawai N et al. The Sleep-Promoting and Hypothermic Effects of Glycine are Mediated by NMDA Receptors in the Suprachiasmatic Nucleus. Neuropsychopharmacology, 2015, 40, 1405.
Vitamin B6: stress, sleep and well-being
[14] Abraham GE et al. Effect of vitamin B-6 on plasma and red blood cell magnesium levels in premenopausal women. Ann Clin Lab Science, 1981, 11, 333.
[16] Sato, K. Why is vitamin B6 effective in alleviating the symptoms of autism? Medical Hypotheses, 2018, 115, 103.
[17] McCarty, MF. High-dose pyridoxine as an anti-stress strategy. Medical Hypotheses 2000, 54, 803.
[18] Doll H et al. Pyridoxine (vitamin B6) and the premenstrual syndrome: A randomized crossover trial. RCGP 1989, 39, 364.
[19] Kafeshani M et al. Higher vitamin B6 intake is associated with lower depression and anxiety risk in women but not in men: A large cross-sectional study. Int J Vit Nutr Res, 2019, 90, 484.
Magnesium + Vitamin B6 synergy
[20] Pouteau E et al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PLoS One, 2018, 13, e0208454.
[21] Noah L et al. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial. Stress Health. 2021, 37, 1000.
[22] Jadidi A et al. Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial. BMC Complement Med Ther. 2022, 31, 1.
Authorized health claims
The magnesium and the vitamin B6 contribute to :
- reduce fatigue,
- normal energy metabolism,
- normal functioning of the nervous system,
- normal muscle function,
- normal psychological functions.
The magnesium contributes to :
- normal muscle function,
- normal psychological functions.